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13 mutational cancer drivers have been detected in this of Colorectal adenocarcinoma (COREAD) project from Johns Hopkins University. The most mutated drivers are: APC, TP53, KRAS, SMAD4, GNAS, etc.



Colorectal adenocarcinoma Johns Hopkins University
COREAD Colorectal adenocarcinoma
36 Samples
Driver / Mut. genes13 / 749
Johns Hopkins University
PMID:17932254
Coding sequence mutations (CSMs)
in driver genes 93
in all genes 1044
Protein affecting mutations (PAMs)
in driver genes 92
in all genes 749
This driver cloud represents the most recurrently mutated cancer driver genes in the Colorectal adenocarcinoma Johns Hopkins University dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Colorectal adenocarcinoma Johns Hopkins University dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
APC ENSG00000134982 24 23 63.89
TP53 ENSG00000141510 17 17 47.22
KRAS ENSG00000133703 16 16 44.44
SMAD4 ENSG00000141646 4 4 11.11
GNAS ENSG00000087460 3 3 8.33
TCF7L2 ENSG00000148737 3 3 8.33
SMAD2 ENSG00000175387 3 3 8.33
TGFBR2 ENSG00000163513 3 3 8.33
NF1 ENSG00000196712 3 3 8.33
PTPRU ENSG00000060656 3 3 8.33
FN1 ENSG00000115414 2 2 5.56
CAD ENSG00000084774 2 2 5.56
AKAP9 ENSG00000127914 2 2 5.56