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155 mutational cancer drivers have been detected in this of Cutaneous melanoma (CM) project from Broad Institute. The most mutated drivers are: ANK3, BRAF, MLL3, SVEP1, HDAC9, etc.



Skin cutaneous melanoma BROAD obtained from Alexandrov
CM Cutaneous melanoma
120 Samples
Driver / Mut. genes155 / 32010
Broad Institute
doi:10.1016/j.cell.2012.06.024
doi:10.1038/nature11071
Coding sequence mutations (CSMs)
in driver genes 1603
in all genes 182071
Protein affecting mutations (PAMs)
in driver genes 1033
in all genes 56552
This driver cloud represents the most recurrently mutated cancer driver genes in the Skin cutaneous melanoma BROAD obtained from Alexandrov dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Skin cutaneous melanoma BROAD obtained from Alexandrov dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
ANK3 ENSG00000151150 52 44 36.67
BRAF ENSG00000157764 77 75 62.50
MLL3 ENSG00000055609 39 28 23.33
SVEP1 ENSG00000165124 28 23 19.17
HDAC9 ENSG00000048052 25 17 14.17
BCLAF1 ENSG00000029363 24 21 17.50
NRAS ENSG00000213281 31 30 25.00
NF1 ENSG00000196712 22 16 13.33
CDKN2A ENSG00000147889 25 24 20.00
MAGI2 ENSG00000187391 19 14 11.67
ARHGAP29 ENSG00000137962 18 16 13.33
TP53 ENSG00000141510 19 18 15.00
TCF4 ENSG00000196628 16 13 10.83
WNK1 ENSG00000060237 11 8 6.67
USP6 ENSG00000129204 13 12 10.00
PTEN ENSG00000171862 15 13 10.83
PPP6C ENSG00000119414 13 11 9.17
CYTH4 ENSG00000100055 12 6 5.00
BRWD1 ENSG00000185658 11 9 7.50
FANCI ENSG00000140525 12 5 4.17
SYK ENSG00000165025 10 6 5.00
MAP3K11 ENSG00000173327 9 5 4.17
RGS3 ENSG00000138835 11 5 4.17
ZNF638 ENSG00000075292 11 6 5.00
WASF3 ENSG00000132970 10 7 5.83
PIK3C2B ENSG00000133056 9 5 4.17
ARID2 ENSG00000189079 9 8 6.67
VIM ENSG00000026025 8 7 5.83
ERBB3 ENSG00000065361 8 5 4.17
FCRL4 ENSG00000163518 7 5 4.17
LNPEP ENSG00000113441 5 5 4.17
CDK4 ENSG00000135446 8 6 5.00
MAP2K1 ENSG00000169032 8 6 5.00
PER1 ENSG00000179094 7 5 4.17
JMY ENSG00000152409 7 5 4.17
FBXW7 ENSG00000109670 4 4 3.33
CRTC3 ENSG00000140577 5 5 4.17
TJP2 ENSG00000119139 6 6 5.00
ACSL3 ENSG00000123983 5 4 3.33
DDX3X ENSG00000215301 6 6 5.00
RHOT1 ENSG00000126858 6 6 5.00
MAT2A ENSG00000168906 6 4 3.33
SMURF2 ENSG00000108854 4 4 3.33
STAG2 ENSG00000101972 20 5 4.17
MKL1 ENSG00000196588 9 2 1.67
EIF4G1 ENSG00000114867 11 5 4.17
MED24 ENSG00000008838 10 4 3.33
FN1 ENSG00000115414 10 4 3.33
NUP107 ENSG00000111581 10 2 1.67
RB1 ENSG00000139687 11 5 4.17
NOTCH1 ENSG00000148400 11 4 3.33
ARHGAP26 ENSG00000145819 9 3 2.50
RUNX1 ENSG00000159216 10 2 1.67
NTN4 ENSG00000074527 9 4 3.33
PIK3CB ENSG00000051382 10 4 3.33
NUP98 ENSG00000110713 8 4 3.33
WT1 ENSG00000184937 9 4 3.33
NFATC4 ENSG00000100968 8 5 4.17
DLG1 ENSG00000075711 8 4 3.33
TBX3 ENSG00000135111 9 3 2.50
ITSN1 ENSG00000205726 7 4 3.33
MLH1 ENSG00000076242 7 3 2.50
FOXP1 ENSG00000114861 7 4 3.33
CLSPN ENSG00000092853 8 3 2.50
BRCA1 ENSG00000012048 8 4 3.33
AFF4 ENSG00000072364 8 4 3.33
PTGS1 ENSG00000095303 9 4 3.33
SF3B1 ENSG00000115524 9 6 5.00
RHOA ENSG00000067560 8 2 1.67
HLA-A ENSG00000206503 8 3 2.50
SOS1 ENSG00000115904 8 5 4.17
PRRX1 ENSG00000116132 8 5 4.17
CIC ENSG00000079432 8 2 1.67
EP300 ENSG00000100393 8 5 4.17
LRP6 ENSG00000070018 6 4 3.33
AQR ENSG00000021776 7 4 3.33
SETDB1 ENSG00000143379 7 3 2.50
BAZ2B ENSG00000123636 8 5 4.17
KDM5C ENSG00000126012 6 2 1.67
POLR2B ENSG00000047315 7 4 3.33
TGFBR2 ENSG00000163513 6 4 3.33
MAP4K3 ENSG00000011566 5 3 2.50
DICER1 ENSG00000100697 7 5 4.17
ATRX ENSG00000085224 6 5 4.17
ARFGEF2 ENSG00000124198 7 4 3.33
CNOT3 ENSG00000088038 7 3 2.50
BNC2 ENSG00000173068 7 5 4.17
SMC1A ENSG00000072501 6 5 4.17
EIF2AK3 ENSG00000172071 5 5 4.17
MAP3K1 ENSG00000095015 6 5 4.17
CAST ENSG00000153113 6 3 2.50
BAP1 ENSG00000163930 6 3 2.50
BMPR2 ENSG00000204217 6 5 4.17
MAP3K4 ENSG00000085511 6 3 2.50
PIK3R1 ENSG00000145675 5 3 2.50
ARID1B ENSG00000049618 5 4 3.33
PAX5 ENSG00000196092 6 2 1.67
SOS2 ENSG00000100485 6 2 1.67
DHX15 ENSG00000109606 6 4 3.33
CCAR1 ENSG00000060339 5 3 2.50
ZMYM2 ENSG00000121741 6 4 3.33
HDAC3 ENSG00000171720 6 2 1.67
TAOK1 ENSG00000160551 5 4 3.33
PIK3CA ENSG00000121879 5 4 3.33
NDRG1 ENSG00000104419 5 3 2.50
CHD3 ENSG00000170004 4 3 2.50
SMAD4 ENSG00000141646 5 2 1.67
CLTC ENSG00000141367 5 2 1.67
ERBB2IP ENSG00000112851 3 2 1.67
CLASP2 ENSG00000163539 5 3 2.50
TFDP1 ENSG00000198176 5 2 1.67
MED17 ENSG00000042429 5 3 2.50
NF2 ENSG00000186575 5 3 2.50
CEP290 ENSG00000198707 4 3 2.50
DNMT3A ENSG00000119772 4 2 1.67
CAT ENSG00000121691 4 3 2.50
ACO1 ENSG00000122729 5 3 2.50
ACTG2 ENSG00000163017 5 2 1.67
NR4A2 ENSG00000153234 5 4 3.33
COPS2 ENSG00000166200 4 2 1.67
TNPO1 ENSG00000083312 5 4 3.33
NCKAP1 ENSG00000061676 5 2 1.67
ACVR1B ENSG00000135503 5 3 2.50
AHR ENSG00000106546 5 4 3.33
CDH1 ENSG00000039068 5 4 3.33
MEN1 ENSG00000133895 4 2 1.67
ATIC ENSG00000138363 4 2 1.67
EZH2 ENSG00000106462 4 4 3.33
NCF2 ENSG00000116701 4 2 1.67
CDC73 ENSG00000134371 4 2 1.67
PPP2R5C ENSG00000078304 3 3 2.50
ZC3H11A ENSG00000058673 4 2 1.67
IDH2 ENSG00000182054 4 4 3.33
CHD1L ENSG00000131778 4 4 3.33
CSNK1G3 ENSG00000151292 4 3 2.50
ZNF814 ENSG00000204514 3 3 2.50
FUBP1 ENSG00000162613 4 2 1.67
NR2F2 ENSG00000185551 3 2 1.67
CYLD ENSG00000083799 4 3 2.50
FGFR3 ENSG00000068078 4 3 2.50
IREB2 ENSG00000136381 3 2 1.67
ELF1 ENSG00000120690 3 3 2.50
ACTG1 ENSG00000184009 3 3 2.50
MAP2K4 ENSG00000065559 3 3 2.50
ARHGEF6 ENSG00000129675 3 3 2.50
FMR1 ENSG00000102081 3 3 2.50
FAS ENSG00000026103 2 2 1.67
RASA1 ENSG00000145715 2 2 1.67
CUL1 ENSG00000055130 2 2 1.67
RAD23B ENSG00000119318 2 2 1.67
B2M ENSG00000166710 2 2 1.67
ARHGAP35 ENSG00000160007 2 2 1.67
SFPQ ENSG00000116560 2 2 1.67
CUL2 ENSG00000108094 2 2 1.67
SEC24D ENSG00000150961 2 2 1.67