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SMAD4 is detected as a mutational cancer driver

SMAD4 reports

Gene details
SMAD4
Ensembl ID ENSG00000141646
Transcript ID ENST00000342988
Protein ID ENSP00000341551
Cancer types where is driver 13
Cohorts where is driver 35
Mutated samples 552
Mutations 872
Mode of action Ambiguous
Known driver True
Method signals per Cancer Type
Cancer type Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
In-silico saturation mutagenesis
Alt text
In silico saturation mutagenesis profiles across all tumor types where a specific model is available. Driver mutations (displayed as red dots) are mapped to their positions in the canonical transcript. The dendrogram on the right represents a hierarchical clustering of the profiles based on site-by-site concordance via Matthews Correlation similarity. The track on the top displays the Pfam domains mapping to the canonical transcript. See the FAQs for more details about the in silico saturation mutagenesis computed with boostDM.
Model Mutations Driver mutations Driver mutations (%)
COREAD (Colorectal Adenocarcinoma) 4959 1319 26.60
ESCA (Esophageal Adenocarcinoma) 4959 706 14.24
PAAD (Pancreatic Adenocarcinoma) 4959 1357 27.36
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Consequence