Top

35 mutational cancer drivers have been detected in this of Breast carcinoma (BRCA) project from Broad Institute. The most mutated drivers are: PIK3CA, TP53, AKT1, MAP3K1, GATA3, etc.



Breast cancer BROAD
BRCA Breast carcinoma
103 Samples
Driver / Mut. genes35 / 5277
Broad Institute
PMID:22722202
Coding sequence mutations (CSMs)
in driver genes 162
in all genes 7011
Protein affecting mutations (PAMs)
in driver genes 153
in all genes 3665
This driver cloud represents the most recurrently mutated cancer driver genes in the Breast cancer BROAD dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Breast cancer BROAD dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
PIK3CA ENSG00000121879 28 28 27.18
TP53 ENSG00000141510 30 30 29.13
AKT1 ENSG00000142208 6 6 5.83
MAP3K1 ENSG00000095015 3 3 2.91
GATA3 ENSG00000107485 4 4 3.88
CBFB ENSG00000067955 4 4 3.88
NOTCH2 ENSG00000134250 3 3 2.91
ERBB2 ENSG00000141736 3 3 2.91
PRKCZ ENSG00000067606 3 3 2.91
NSD1 ENSG00000165671 3 3 2.91
TAF1 ENSG00000147133 4 2 1.94
ATM ENSG00000149311 4 4 3.88
EGFR ENSG00000146648 4 3 2.91
MLL ENSG00000118058 3 3 2.91
MECOM ENSG00000085276 3 3 2.91
AHNAK ENSG00000124942 3 3 2.91
KALRN ENSG00000160145 3 3 2.91
MLL2 ENSG00000167548 3 2 1.94
NCOR1 ENSG00000141027 3 2 1.94
KDM5C ENSG00000126012 3 3 2.91
CDH1 ENSG00000039068 3 2 1.94
MED12 ENSG00000184634 3 3 2.91
BCOR ENSG00000183337 2 2 1.94
SMARCA4 ENSG00000127616 2 2 1.94
SOS2 ENSG00000100485 2 2 1.94
FOXP1 ENSG00000114861 2 2 1.94
MTOR ENSG00000198793 2 2 1.94
MAP2K4 ENSG00000065559 2 2 1.94
MGA ENSG00000174197 2 2 1.94
BRCA1 ENSG00000012048 2 2 1.94
NR4A2 ENSG00000153234 2 2 1.94
ARID1A ENSG00000117713 2 2 1.94
BNC2 ENSG00000173068 2 2 1.94
CHD9 ENSG00000177200 2 2 1.94
SF3B1 ENSG00000115524 2 2 1.94