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BRAF is detected as a mutational cancer driver

BRAF reports

Gene details
BRAF
Ensembl ID ENSG00000157764
Transcript ID ENST00000496384
Protein ID ENSP00000419060
Cancer types where is driver 22
Cohorts where is driver 52
Mutated samples 1,416
Mutations 1,786
Mode of action Ambiguous
Known driver True
Method signals per Cancer Type
Cancer type Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
In-silico saturation mutagenesis
Alt text
In silico saturation mutagenesis profiles across all tumor types where a specific model is available. Driver mutations (displayed as red dots) are mapped to their positions in the canonical transcript. The dendrogram on the right represents a hierarchical clustering of the profiles based on site-by-site concordance via Matthews Correlation similarity. The track on the top displays the Pfam domains mapping to the canonical transcript. See the FAQs for more details about the in silico saturation mutagenesis computed with boostDM.
Model Mutations Driver mutations Driver mutations (%)
COREAD (Colorectal Adenocarcinoma) 6885 244 3.54
LUAD (Lung Adenocarcinoma) 6885 333 4.84
LUNG_CANCER (Lung) 6885 108 1.57
CM (Melanoma) 6885 82 1.19
MM (Plasma Cell Myeloma) 6885 121 1.76
THCA (Well-Differentiated Thyroid Cancer) 6885 6 0.09
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Consequence