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24 mutational cancer drivers have been detected in this of Breast carcinoma (BRCA) project from British Columbia University. The most mutated drivers are: TP53, PIK3CA, RB1, LPHN2, PTEN, etc.



Triple Negative Breast Cancer UBC
BRCA Breast carcinoma
65 Samples
Driver / Mut. genes24 / 2935
British Columbia University
PMID:22495314
Coding sequence mutations (CSMs)
in driver genes 92
in all genes 3435
Protein affecting mutations (PAMs)
in driver genes 90
in all genes 2401
This driver cloud represents the most recurrently mutated cancer driver genes in the Triple Negative Breast Cancer UBC dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Triple Negative Breast Cancer UBC dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 34 34 52.31
PIK3CA ENSG00000121879 6 6 9.23
RB1 ENSG00000139687 3 3 4.62
LPHN2 ENSG00000117114 3 3 4.62
PTEN ENSG00000171862 3 3 4.62
FLT3 ENSG00000122025 2 2 3.08
NRAS ENSG00000213281 3 2 3.08
MACF1 ENSG00000127603 2 2 3.08
CASP8 ENSG00000064012 3 2 3.08
TAF1 ENSG00000147133 2 2 3.08
PCDH18 ENSG00000189184 2 2 3.08
BRAF ENSG00000157764 2 2 3.08
RHEB ENSG00000106615 2 2 3.08
MLL3 ENSG00000055609 2 2 3.08
AHNAK ENSG00000124942 2 2 3.08
ASH1L ENSG00000116539 2 2 3.08
KALRN ENSG00000160145 2 2 3.08
MYH11 ENSG00000133392 2 2 3.08
LRP6 ENSG00000070018 2 2 3.08
PTPRU ENSG00000060656 2 2 3.08
ARID2 ENSG00000189079 2 2 3.08
CDH1 ENSG00000039068 2 2 3.08
ANK3 ENSG00000151150 2 2 3.08
MED12 ENSG00000184634 2 2 3.08