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156 mutational cancer drivers have been detected in this of Bladder carcinoma (BLCA) project from The Cancer Genome Atlas. The most mutated drivers are: TP53, MLL2, ARID1A, MLL3, KDM6A, etc.



Bladder urothelial carcinoma TCGA
BLCA Bladder carcinoma
98 Samples
Driver / Mut. genes156 / 17012
The Cancer Genome Atlas
doi:10.1038/nature12965
Coding sequence mutations (CSMs)
in driver genes 954
in all genes 42075
Protein affecting mutations (PAMs)
in driver genes 816
in all genes 20707
This driver cloud represents the most recurrently mutated cancer driver genes in the Bladder urothelial carcinoma TCGA dataset. The size of the gene symbol is relative to the count of samples with PAMs.
This plot shows the most recurrently mutated cancer driver genes in the Bladder urothelial carcinoma TCGA dataset. Each bar of the histogram indicates the amount of samples with PAMs.

Gene symbol Ensembl id Driver class Mutated samples % Mutated samples
TP53 ENSG00000141510 49 49 50.00
MLL2 ENSG00000167548 28 24 24.49
ARID1A ENSG00000117713 28 27 27.55
MLL3 ENSG00000055609 26 24 24.49
KDM6A ENSG00000147050 28 26 26.53
AHNAK ENSG00000124942 14 12 12.24
EP300 ENSG00000100393 17 17 17.35
RB1 ENSG00000139687 16 14 14.29
FAT1 ENSG00000083857 13 12 12.24
STAG2 ENSG00000101972 15 10 10.20
ELF3 ENSG00000163435 8 8 8.16
CDKN1A ENSG00000124762 12 12 12.24
ERCC2 ENSG00000104884 12 12 12.24
FGFR3 ENSG00000068078 9 8 8.16
TRIO ENSG00000038382 10 10 10.20
FBXW7 ENSG00000109670 9 9 9.18
ERBB3 ENSG00000065361 10 10 10.20
MGA ENSG00000174197 6 6 6.12
NFE2L2 ENSG00000116044 9 9 9.18
SETD2 ENSG00000181555 8 8 8.16
LIMA1 ENSG00000050405 6 6 6.12
NCOR2 ENSG00000196498 7 7 7.14
ARHGAP35 ENSG00000160007 5 5 5.10
TXNIP ENSG00000117289 5 5 5.10
TSC1 ENSG00000165699 6 6 6.12
MECOM ENSG00000085276 5 5 5.10
PCDH18 ENSG00000189184 5 5 5.10
FKBP5 ENSG00000096060 5 5 5.10
TAOK2 ENSG00000149930 12 5 5.10
HSP90AA1 ENSG00000080824 7 5 5.10
CNOT1 ENSG00000125107 7 3 3.06
CAD ENSG00000084774 6 5 5.10
EIF4A2 ENSG00000156976 6 2 2.04
CDH1 ENSG00000039068 6 5 5.10
NUP98 ENSG00000110713 7 5 5.10
MYH10 ENSG00000133026 6 5 5.10
MED12 ENSG00000184634 7 5 5.10
CHD3 ENSG00000170004 6 3 3.06
BAP1 ENSG00000163930 5 4 4.08
BMPR2 ENSG00000204217 6 4 4.08
NUP107 ENSG00000111581 6 5 5.10
ARID1B ENSG00000049618 6 4 4.08
KEAP1 ENSG00000079999 3 3 3.06
DDX5 ENSG00000108654 6 4 4.08
ATR ENSG00000175054 6 4 4.08
CIC ENSG00000079432 5 2 2.04
ZFP36L2 ENSG00000152518 5 3 3.06
ZNF814 ENSG00000204514 6 4 4.08
CDK12 ENSG00000167258 6 4 4.08
NOTCH1 ENSG00000148400 6 4 4.08
BCLAF1 ENSG00000029363 5 5 5.10
ANK3 ENSG00000151150 5 4 4.08
RHOA ENSG00000067560 5 4 4.08
IREB2 ENSG00000136381 5 3 3.06
CLTC ENSG00000141367 4 2 2.04
MAP3K4 ENSG00000085511 4 4 4.08
GPS2 ENSG00000132522 4 3 3.06
ACTB ENSG00000075624 5 4 4.08
MAP4K3 ENSG00000011566 4 3 3.06
CARM1 ENSG00000142453 5 3 3.06
PIK3CB ENSG00000051382 2 2 2.04
BRCA1 ENSG00000012048 5 4 4.08
MET ENSG00000105976 3 3 3.06
EIF4G1 ENSG00000114867 4 3 3.06
PIP5K1A ENSG00000143398 2 2 2.04
MED24 ENSG00000008838 5 2 2.04
HSP90AB1 ENSG00000096384 5 4 4.08
STAG1 ENSG00000118007 4 3 3.06
CHD9 ENSG00000177200 4 4 4.08
CDKN2A ENSG00000147889 4 4 4.08
CASP8 ENSG00000064012 5 4 4.08
EIF2AK3 ENSG00000172071 4 2 2.04
MAP3K1 ENSG00000095015 4 3 3.06
HNRPDL ENSG00000152795 4 4 4.08
FN1 ENSG00000115414 4 4 4.08
HSPA8 ENSG00000109971 4 3 3.06
BCOR ENSG00000183337 4 3 3.06
CHEK2 ENSG00000183765 4 2 2.04
APC ENSG00000134982 4 4 4.08
MLH1 ENSG00000076242 4 3 3.06
CEP290 ENSG00000198707 4 4 4.08
SOS1 ENSG00000115904 3 3 3.06
DICER1 ENSG00000100697 4 3 3.06
NCF2 ENSG00000116701 4 3 3.06
SOS2 ENSG00000100485 4 3 3.06
KLF6 ENSG00000067082 2 2 2.04
NRAS ENSG00000213281 4 2 2.04
CSDE1 ENSG00000009307 4 2 2.04
BLM ENSG00000197299 4 4 4.08
CTCF ENSG00000102974 4 2 2.04
GNAS ENSG00000087460 4 4 4.08
ZMYM2 ENSG00000121741 3 3 3.06
AFF4 ENSG00000072364 4 4 4.08
AHR ENSG00000106546 4 4 4.08
HRAS ENSG00000174775 4 4 4.08
SF3B1 ENSG00000115524 4 4 4.08
TAF1 ENSG00000147133 3 2 2.04
NAP1L1 ENSG00000187109 3 3 3.06
RASA1 ENSG00000145715 3 3 3.06
DLG1 ENSG00000075711 3 3 3.06
BRAF ENSG00000157764 2 2 2.04
HLA-A ENSG00000206503 3 3 3.06
ERBB2IP ENSG00000112851 3 2 2.04
IDH1 ENSG00000138413 3 3 3.06
TBX3 ENSG00000135111 3 3 3.06
DDX3X ENSG00000215301 2 2 2.04
TGFBR2 ENSG00000163513 3 3 3.06
CLASP2 ENSG00000163539 3 3 3.06
FLT3 ENSG00000122025 3 2 2.04
ACTG1 ENSG00000184009 3 3 3.06
GOLGA5 ENSG00000066455 3 3 3.06
FGFR2 ENSG00000066468 3 2 2.04
DIS3 ENSG00000083520 3 2 2.04
G3BP2 ENSG00000138757 3 3 3.06
CAT ENSG00000121691 3 3 3.06
SUZ12 ENSG00000178691 3 3 3.06
MYH11 ENSG00000133392 3 3 3.06
CLSPN ENSG00000092853 3 2 2.04
ARFGEF2 ENSG00000124198 3 3 3.06
AQR ENSG00000021776 3 2 2.04
CDKN1B ENSG00000111276 2 2 2.04
COPS2 ENSG00000166200 3 3 3.06
FUS ENSG00000089280 3 3 3.06
CUL2 ENSG00000108094 3 3 3.06
PHF6 ENSG00000156531 3 3 3.06
TP53BP1 ENSG00000067369 3 3 3.06
SMC1A ENSG00000072501 3 3 3.06
RAD21 ENSG00000164754 2 2 2.04
PTEN ENSG00000171862 3 3 3.06
ARHGAP26 ENSG00000145819 3 3 3.06
TAOK1 ENSG00000160551 2 2 2.04
RBM5 ENSG00000003756 2 2 2.04
CTNNB1 ENSG00000168036 2 2 2.04
TBL1XR1 ENSG00000177565 2 2 2.04
NDRG1 ENSG00000104419 2 2 2.04
CAST ENSG00000153113 2 2 2.04
SMAD4 ENSG00000141646 2 2 2.04
ELF1 ENSG00000120690 2 2 2.04
EEF1B2 ENSG00000114942 2 2 2.04
STK4 ENSG00000101109 2 2 2.04
IRS2 ENSG00000185950 2 2 2.04
CCT5 ENSG00000150753 2 2 2.04
RPSAP58 ENSG00000205246 2 2 2.04
ADAM10 ENSG00000137845 2 2 2.04
MTOR ENSG00000198793 2 2 2.04
SFPQ ENSG00000116560 2 2 2.04
CCAR1 ENSG00000060339 2 2 2.04
THRAP3 ENSG00000054118 2 2 2.04
TNPO1 ENSG00000083312 2 2 2.04
SETDB1 ENSG00000143379 2 2 2.04
SF3A3 ENSG00000183431 2 2 2.04
ACSL6 ENSG00000164398 2 2 2.04
PTPRU ENSG00000060656 2 2 2.04
ARFGAP1 ENSG00000101199 2 2 2.04
FAM123B ENSG00000184675 2 2 2.04
PCSK6 ENSG00000140479 2 2 2.04