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ZC3H4 has not been detected as a mutational cancer driver

ZC3H4
Ensembl id ENSG00000130749
Mutated samples
Coding Sequence 86 (1.3%)
Protein Affecting 63 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ZC3H4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 25 19 5.15
Head and neck squamous cell carcinoma No 11 9 2.40
Stomach adenocarcinoma No 7 7 4.35
Lung adenocarcinoma No 8 6 1.53
Uterine corpus endometrioid carcinoma No 5 4 1.74
Lung squamous cell carcinoma No 4 3 1.72
Serous ovarian adenocarcinoma No 4 3 0.95
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 3 2 2.04
Thyroid carcinoma No 3 2 0.62
Colorectal adenocarcinoma No 2 2 0.87
Breast carcinoma No 2 1 0.09
Renal clear cell carcinoma No 1 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Esophageal carcinoma No 3 1 0.68
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence