IntOGen - WRN gene cancer mutations

WRN is detected as a mutational cancer driver

WRN reports

Methods
Mutation distribution

Gene details

WRN
Ensembl ID ENSG00000165392 Transcript ID ENST00000298139 Protein ID ENSP00000298139
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 2 Mutations 292
Mode of action Loss of function
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence