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UPF2 has not been detected as a mutational cancer driver

UPF2
Ensembl id ENSG00000151461
Mutated samples
Coding Sequence 91 (1.3%)
Protein Affecting 70 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UPF2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 24 6.50
Lung squamous cell carcinoma No 7 6 3.45
Stomach adenocarcinoma No 8 6 3.73
Breast carcinoma No 7 5 0.44
Head and neck squamous cell carcinoma No 7 5 1.33
Lung adenocarcinoma No 5 4 1.02
Renal clear cell carcinoma No 5 4 0.96
Small cell lung carcinoma No 3 3 4.35
Esophageal carcinoma No 3 3 2.05
Bladder carcinoma No 3 2 2.04
Uterine corpus endometrioid carcinoma No 2 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Colorectal adenocarcinoma No 2 2 0.87
Prostate adenocarcinoma No 1 1 0.41
Multiple myeloma No 1 1 1.45
Neuroblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence