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TSC1 is detected as a mutational cancer driver in 1 cancer type: Bladder carcinoma

TSC1
Ensembl id ENSG00000165699
Mutated samples
Coding Sequence 72 (1.1%)
Protein Affecting 44 (0.6%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
BLCA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TSC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Bladder carcinoma Yes 6 6 6.12
Lung adenocarcinoma No 8 7 1.79
Breast carcinoma No 9 5 0.44
Cutaneous melanoma No 13 5 1.36
Lung squamous cell carcinoma No 6 4 2.30
Stomach adenocarcinoma No 7 4 2.48
Uterine corpus endometrioid carcinoma No 4 3 1.30
Renal clear cell carcinoma No 2 2 0.48
Neuroblastoma No 2 2 0.95
Serous ovarian adenocarcinoma No 3 2 0.63
Head and neck squamous cell carcinoma No 3 2 0.53
Hepatocarcinoma No 1 1 1.11
Lower grade glioma No 1 1 0.59
Chronic lymphocytic leukemia No 3 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
Glioblastoma multiforme No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence