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TRPM2 has not been detected as a mutational cancer driver

TRPM2
Ensembl id ENSG00000142185
Mutated samples
Coding Sequence 145 (2.1%)
Protein Affecting 93 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TRPM2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 57 34 9.21
Lung adenocarcinoma No 15 11 2.81
Glioblastoma multiforme No 10 7 1.85
Breast carcinoma No 10 6 0.52
Lung squamous cell carcinoma No 8 6 3.45
Head and neck squamous cell carcinoma No 11 6 1.60
Uterine corpus endometrioid carcinoma No 6 4 1.74
Stomach adenocarcinoma No 6 4 2.48
Bladder carcinoma No 5 3 3.06
Serous ovarian adenocarcinoma No 3 3 0.95
Colorectal adenocarcinoma No 3 2 0.87
Renal clear cell carcinoma No 3 1 0.24
Thyroid carcinoma No 1 1 0.31
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Pancreas adenocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence