TOM1 mutations in 4 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Breast carcinoma, Lung squamous cell carcinoma, Serous ovarian adenocarcinoma

Ensembl id ENSG00000100284
Mutated samples
Coding Sequence 37 (0.5%)
Protein Affecting 27 (0.4%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TOM1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 7 6 0.52
Lung adenocarcinoma Yes 3 3 0.77
Serous ovarian adenocarcinoma Yes 3 3 0.95
Lung squamous cell carcinoma Yes 3 2 1.15
Cutaneous melanoma No 14 7 1.90
Bladder carcinoma No 1 1 1.02
Renal clear cell carcinoma No 1 1 0.24
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 1 1 0.27
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence