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TMTC2 has not been detected as a mutational cancer driver

TMTC2
Ensembl id ENSG00000179104
Mutated samples
Coding Sequence 89 (1.3%)
Protein Affecting 59 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TMTC2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 10 9 2.40
Breast carcinoma No 9 7 0.61
Cutaneous melanoma No 11 7 1.90
Lung squamous cell carcinoma No 4 4 2.30
Esophageal carcinoma No 4 4 2.74
Lung adenocarcinoma No 4 3 0.77
Renal clear cell carcinoma No 4 3 0.72
Stomach adenocarcinoma No 4 3 1.86
Chronic lymphocytic leukemia No 16 2 0.69
Serous ovarian adenocarcinoma No 2 2 0.63
Diffuse B cell lymphoma No 3 2 8.70
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 3 1 1.02
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Uterine corpus endometrioid carcinoma No 1 1 0.43
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence