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TMEM8B has not been detected as a mutational cancer driver

TMEM8B
Ensembl id ENSG00000137103
Mutated samples
Coding Sequence 85 (1.3%)
Protein Affecting 21 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TMEM8B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 28 4 1.08
Stomach adenocarcinoma No 8 4 2.48
Uterine corpus endometrioid carcinoma No 8 3 1.30
Breast carcinoma No 5 2 0.17
Lung squamous cell carcinoma No 7 2 1.15
Multiple myeloma No 2 2 2.90
Esophageal carcinoma No 4 2 1.37
Lung adenocarcinoma No 4 1 0.26
Serous ovarian adenocarcinoma No 3 1 0.32
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 4 0 0.00
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Head and neck squamous cell carcinoma No 3 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence