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TMEM176B has not been detected as a mutational cancer driver

TMEM176B
Ensembl id ENSG00000106565
Mutated samples
Coding Sequence 73 (1.1%)
Protein Affecting 29 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TMEM176B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 39 18 4.88
Lung adenocarcinoma No 8 2 0.51
Lung squamous cell carcinoma No 5 2 1.15
Head and neck squamous cell carcinoma No 3 2 0.53
Thyroid carcinoma No 2 1 0.31
Uterine corpus endometrioid carcinoma No 3 1 0.43
Serous ovarian adenocarcinoma No 3 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Small cell lung carcinoma No 1 1 1.45
Prostate adenocarcinoma No 2 0 0.00
Hepatocarcinoma No 1 0 0.00
Breast carcinoma No 1 0 0.00
Medulloblastoma No 3 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence