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TLL2 has not been detected as a mutational cancer driver

TLL2
Ensembl id ENSG00000095587
Mutated samples
Coding Sequence 87 (1.3%)
Protein Affecting 67 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TLL2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 20 5.42
Lung adenocarcinoma No 15 11 2.81
Breast carcinoma No 6 6 0.52
Colorectal adenocarcinoma No 6 5 2.18
Bladder carcinoma No 3 3 3.06
Stomach adenocarcinoma No 3 3 1.86
Glioblastoma multiforme No 5 3 0.79
Lung squamous cell carcinoma No 2 2 1.15
Renal clear cell carcinoma No 3 2 0.48
Uterine corpus endometrioid carcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 4 1 0.34
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 2 1 0.68
Pancreas adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence