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THBS1 has not been detected as a mutational cancer driver

THBS1
Ensembl id ENSG00000137801
Mutated samples
Coding Sequence 98 (1.4%)
Protein Affecting 69 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all THBS1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 42 27 7.32
Renal clear cell carcinoma No 7 7 1.68
Head and neck squamous cell carcinoma No 7 7 1.87
Breast carcinoma No 7 4 0.35
Uterine corpus endometrioid carcinoma No 7 4 1.74
Stomach adenocarcinoma No 5 4 2.48
Prostate adenocarcinoma No 3 3 1.23
Colorectal adenocarcinoma No 3 3 1.31
Glioblastoma multiforme No 4 3 0.79
Lung adenocarcinoma No 3 2 0.51
Serous ovarian adenocarcinoma No 3 2 0.63
Small cell lung carcinoma No 2 2 2.90
Thyroid carcinoma No 1 1 0.31
Hepatocarcinoma No 1 0 0.00
Lower grade glioma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence