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TEK has not been detected as a mutational cancer driver

TEK
Ensembl id ENSG00000120156
Mutated samples
Coding Sequence 100 (1.5%)
Protein Affecting 75 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TEK gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 22 5.96
Uterine corpus endometrioid carcinoma No 8 7 3.04
Lung adenocarcinoma No 7 6 1.53
Breast carcinoma No 8 6 0.52
Stomach adenocarcinoma No 7 5 3.11
Head and neck squamous cell carcinoma No 5 5 1.33
Lung squamous cell carcinoma No 5 4 2.30
Glioblastoma multiforme No 5 4 1.06
Colorectal adenocarcinoma No 3 3 1.31
Thyroid carcinoma No 2 2 0.62
Serous ovarian adenocarcinoma No 2 2 0.63
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 2 1 1.02
Acute myeloid leukemia No 1 1 0.51
Medulloblastoma No 1 1 0.48
Renal clear cell carcinoma No 2 1 0.24
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 1 1 0.68
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence