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TBC1D5 has not been detected as a mutational cancer driver

TBC1D5
Ensembl id ENSG00000131374
Mutated samples
Coding Sequence 137 (2.0%)
Protein Affecting 42 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TBC1D5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 40 11 2.98
Lung adenocarcinoma No 13 8 2.05
Head and neck squamous cell carcinoma No 12 5 1.33
Breast carcinoma No 11 4 0.35
Stomach adenocarcinoma No 7 3 1.86
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 3 2 2.04
Lung squamous cell carcinoma No 6 2 1.15
Serous ovarian adenocarcinoma No 3 2 0.63
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Esophageal carcinoma No 3 1 0.68
Hepatocarcinoma No 3 0 0.00
Medulloblastoma No 4 0 0.00
Uterine corpus endometrioid carcinoma No 11 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 11 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence