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STK11 is detected as a mutational cancer driver in 1 cancer type: Lung adenocarcinoma and in the PAN-cancer analysis

STK11
Ensembl id ENSG00000118046
Mutated samples
Coding Sequence 84 (1.2%)
Protein Affecting 68 (1.0%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
LUAD FR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all STK11 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Yes 54 54 13.81
Cutaneous melanoma Yes 8 4 1.08
Breast carcinoma Yes 3 3 0.26
Lung squamous cell carcinoma Yes 5 3 1.72
Renal clear cell carcinoma No 3 1 0.24
Uterine corpus endometrioid carcinoma No 1 1 0.43
Head and neck squamous cell carcinoma No 2 1 0.27
Esophageal carcinoma No 1 1 0.68
Bladder carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
Stomach adenocarcinoma No 2 0 0.00
Small cell lung carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence