STK11 is detected as a mutational cancer driver in 1 cancer type: Lung adenocarcinoma and in the PAN-cancer analysis
| STK11 |
|---|
| Ensembl id ENSG00000118046 |
| Mutated samples
Coding Sequence 84 (1.2%) Protein Affecting 68 (1.0%) |
| Mode of action Loss of function |
| Known driver Yes |
| Cancer type | Signals (Biases) |
|---|---|
| LUAD | FR |
| PAN |
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all STK11 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.
| Cancer type | Driver | Mutated samples (CS) | Mutated samples (PAM) | % Mutated samples (PAM) |
|---|---|---|---|---|
| Lung adenocarcinoma | Yes | 54 | 54 | 13.81 |
| Cutaneous melanoma | Yes | 8 | 4 | 1.08 |
| Breast carcinoma | Yes | 3 | 3 | 0.26 |
| Lung squamous cell carcinoma | Yes | 5 | 3 | 1.72 |
| Renal clear cell carcinoma | No | 3 | 1 | 0.24 |
| Uterine corpus endometrioid carcinoma | No | 1 | 1 | 0.43 |
| Head and neck squamous cell carcinoma | No | 2 | 1 | 0.27 |
| Esophageal carcinoma | No | 1 | 1 | 0.68 |
| Bladder carcinoma | No | 1 | 0 | 0.00 |
| Chronic lymphocytic leukemia | No | 1 | 0 | 0.00 |
| Lower grade glioma | No | 1 | 0 | 0.00 |
| Stomach adenocarcinoma | No | 2 | 0 | 0.00 |
| Small cell lung carcinoma | No | 1 | 0 | 0.00 |
| Diffuse B cell lymphoma | No | 1 | 0 | 0.00 |
Choose a transcript:
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.
| Variant Locus | Samples | AA pos | AA change | Consequence |
|---|