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STAG1 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

STAG1
Ensembl id ENSG00000118007
Mutated samples
Coding Sequence 104 (1.5%)
Protein Affecting 83 (1.2%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all STAG1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 22 20 5.42
Breast carcinoma Yes 11 9 0.78
Lung squamous cell carcinoma Yes 8 5 2.87
Bladder carcinoma Yes 4 3 3.06
Neuroblastoma Yes 3 3 1.43
Lung adenocarcinoma Yes 4 2 0.51
Serous ovarian adenocarcinoma Yes 2 2 0.63
Stomach adenocarcinoma No 8 7 4.35
Uterine corpus endometrioid carcinoma No 6 6 2.61
Renal clear cell carcinoma No 6 5 1.20
Colorectal adenocarcinoma No 5 5 2.18
Head and neck squamous cell carcinoma No 5 5 1.33
Esophageal carcinoma No 5 4 2.74
Prostate adenocarcinoma No 1 1 0.41
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 3 1 1.45
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence