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SRPK2 has not been detected as a mutational cancer driver

SRPK2
Ensembl id ENSG00000135250
Mutated samples
Coding Sequence 106 (1.6%)
Protein Affecting 30 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SRPK2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 13 6 1.60
Cutaneous melanoma No 20 5 1.36
Lung adenocarcinoma No 6 4 1.02
Stomach adenocarcinoma No 10 3 1.86
Breast carcinoma No 10 2 0.17
Renal clear cell carcinoma No 6 2 0.48
Glioblastoma multiforme No 3 2 0.53
Hepatocarcinoma No 3 1 1.11
Bladder carcinoma No 1 1 1.02
Lung squamous cell carcinoma No 4 1 0.57
Lower grade glioma No 2 1 0.59
Serous ovarian adenocarcinoma No 5 1 0.32
Esophageal carcinoma No 4 1 0.68
Prostate adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 2 0 0.00
Neuroblastoma No 2 0 0.00
Uterine corpus endometrioid carcinoma No 2 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 8 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence