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SMARCB1 is detected as a mutational cancer driver in 1 cancer type: Prostate adenocarcinoma

SMARCB1
Ensembl id ENSG00000099956
Mutated samples
Coding Sequence 58 (0.9%)
Protein Affecting 32 (0.5%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
PRAD F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SMARCB1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Prostate adenocarcinoma Yes 3 3 1.23
Uterine corpus endometrioid carcinoma No 6 4 1.74
Serous ovarian adenocarcinoma No 5 4 1.27
Renal clear cell carcinoma No 6 3 0.72
Cutaneous melanoma No 9 3 0.81
Lower grade glioma No 2 2 1.18
Head and neck squamous cell carcinoma No 3 2 0.53
Esophageal carcinoma No 3 2 1.37
Lung adenocarcinoma No 1 1 0.26
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 2 1 1.02
Breast carcinoma No 3 1 0.09
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 1 1 0.57
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 3 1 0.44
Diffuse B cell lymphoma No 1 1 4.35
Non small cell lung carcinoma No 1 0 0.00
Stomach adenocarcinoma No 3 0 0.00
Small cell lung carcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence