IntOGen - SMAD3 gene cancer mutations in PAAD

SMAD3 is detected as a mutational cancer driver in Pancreatic Adenocarcinoma

SMAD3 reports in Pancreatic Adenocarcinoma (PAAD)

Methods
Mutation distribution

Cancer type details

Pancreatic Adenocarcinoma
Cohorts 7 Samples 922 Mutations 2,520,434 Driver genes 64

Gene details

SMAD3
Ensembl ID ENSG00000166949 Transcript ID ENST00000327367 Protein ID ENSP00000332973
Cohorts where is driver 1 Mutated samples 2 Mutated samples (%) 0.22 Mutations 11
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence