IntOGen - SETD2 gene cancer mutations in GBM

SETD2 is detected as a mutational cancer driver in Glioblastoma Multiforme

SETD2 reports in Glioblastoma Multiforme (GBM)

Methods
Mutation distribution

Cancer type details

Glioblastoma Multiforme
Cohorts 5 Samples 673 Mutations 3,702,787 Driver genes 52

Gene details

SETD2
Ensembl ID ENSG00000181555 Transcript ID ENST00000409792 Protein ID ENSP00000386759
Cohorts where is driver 1 Mutated samples 2 Mutated samples (%) 0.30 Mutations 18
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence