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SEMA3E has not been detected as a mutational cancer driver

SEMA3E
Ensembl id ENSG00000170381
Mutated samples
Coding Sequence 132 (1.9%)
Protein Affecting 86 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SEMA3E gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 41 29 7.86
Head and neck squamous cell carcinoma No 12 10 2.67
Glioblastoma multiforme No 8 8 2.11
Lung squamous cell carcinoma No 9 6 3.45
Stomach adenocarcinoma No 11 6 3.73
Lung adenocarcinoma No 4 4 1.02
Small cell lung carcinoma No 3 3 4.35
Colorectal adenocarcinoma No 4 3 1.31
Prostate adenocarcinoma No 2 2 0.82
Hepatocarcinoma No 4 2 2.22
Breast carcinoma No 4 2 0.17
Renal clear cell carcinoma No 3 2 0.48
Uterine corpus endometrioid carcinoma No 3 2 0.87
Chronic lymphocytic leukemia No 14 2 0.69
Medulloblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 3 1 0.32
Acute lymphocytic leukemia No 1 1 0.82
Bladder carcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence