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SEMA3A has not been detected as a mutational cancer driver

SEMA3A
Ensembl id ENSG00000075213
Mutated samples
Coding Sequence 115 (1.7%)
Protein Affecting 66 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SEMA3A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 17 15 3.84
Cutaneous melanoma No 19 10 2.71
Head and neck squamous cell carcinoma No 13 10 2.67
Breast carcinoma No 7 5 0.44
Stomach adenocarcinoma No 6 5 3.11
Bladder carcinoma No 4 4 4.08
Uterine corpus endometrioid carcinoma No 4 3 1.30
Acute myeloid leukemia No 2 2 1.02
Lung squamous cell carcinoma No 2 2 1.15
Renal clear cell carcinoma No 3 2 0.48
Serous ovarian adenocarcinoma No 2 2 0.63
Prostate adenocarcinoma No 1 1 0.41
Thyroid carcinoma No 1 1 0.31
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 6 0 0.00
Chronic lymphocytic leukemia No 20 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence