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RUNX1 × Acute Myeloid Leukemia ×

RUNX1 is detected as a mutational cancer driver in Acute Myeloid Leukemia

RUNX1 reports in Acute Myeloid Leukemia (AML)

Cancer type details
Acute Myeloid Leukemia
Cohorts 9
Samples 661
Mutations 295,755
Driver genes 62
Gene details
RUNX1
Ensembl ID ENSG00000159216
Transcript ID ENST00000300305
Protein ID ENSP00000300305
Cohorts where is driver 2
Mutated samples 28
Mutated samples (%) 4.24
Mutations 38
Mode of action Loss of function
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence