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RP1L1 has not been detected as a mutational cancer driver

RP1L1
Ensembl id ENSG00000183638
Mutated samples
Coding Sequence 278 (4.1%)
Protein Affecting 190 (2.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RP1L1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 95 65 17.62
Lung adenocarcinoma No 51 40 10.23
Stomach adenocarcinoma No 21 13 8.07
Lung squamous cell carcinoma No 16 12 6.90
Serous ovarian adenocarcinoma No 8 7 2.22
Head and neck squamous cell carcinoma No 14 7 1.87
Bladder carcinoma No 9 6 6.12
Prostate adenocarcinoma No 6 5 2.06
Colorectal adenocarcinoma No 6 5 2.18
Esophageal carcinoma No 7 5 3.42
Breast carcinoma No 7 4 0.35
Renal clear cell carcinoma No 5 4 0.96
Uterine corpus endometrioid carcinoma No 9 4 1.74
Small cell lung carcinoma No 4 4 5.80
Chronic lymphocytic leukemia No 4 3 1.03
Glioblastoma multiforme No 5 3 0.79
Medulloblastoma No 1 1 0.48
Neuroblastoma No 2 1 0.48
Lower grade glioma No 2 1 0.59
Hepatocarcinoma No 2 0 0.00
Acute myeloid leukemia No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence