IntOGen - RNF43 gene cancer mutations in UCEC

RNF43 is detected as a mutational cancer driver in Endometrial Carcinoma

RNF43 reports in Endometrial Carcinoma (UCEC)

Methods
Mutation distribution

Cancer type details

Endometrial Carcinoma
Cohorts 4 Samples 691 Mutations 3,631,382 Driver genes 69

Gene details

RNF43
Ensembl ID ENSG00000108375 Transcript ID ENST00000584437 Protein ID ENSP00000463069
Cohorts where is driver 1 Mutated samples 18 Mutated samples (%) 2.60 Mutations 63
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence