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RIT2 has not been detected as a mutational cancer driver

RIT2
Ensembl id ENSG00000152214
Mutated samples
Coding Sequence 67 (1.0%)
Protein Affecting 44 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RIT2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 22 15 4.07
Lung adenocarcinoma No 6 5 1.28
Lung squamous cell carcinoma No 6 5 2.87
Stomach adenocarcinoma No 4 4 2.48
Head and neck squamous cell carcinoma No 4 3 0.80
Bladder carcinoma No 2 2 2.04
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 1 0.68
Chronic lymphocytic leukemia No 11 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence