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RIT1 has not been detected as a mutational cancer driver

RIT1
Ensembl id ENSG00000143622
Mutated samples
Coding Sequence 35 (0.5%)
Protein Affecting 22 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RIT1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 8 6 1.53
Cutaneous melanoma No 6 5 1.36
Small cell lung carcinoma No 2 2 2.90
Esophageal carcinoma No 3 2 1.37
Bladder carcinoma No 2 1 1.02
Acute myeloid leukemia No 1 1 0.51
Breast carcinoma No 3 1 0.09
Lung squamous cell carcinoma No 1 1 0.57
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 2 1 0.44
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence