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RIMS2 has not been detected as a mutational cancer driver

RIMS2
Ensembl id ENSG00000176406
Mutated samples
Coding Sequence 306 (4.5%)
Protein Affecting 248 (3.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RIMS2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 64 52 14.09
Lung adenocarcinoma No 40 38 9.72
Head and neck squamous cell carcinoma No 24 23 6.13
Lung squamous cell carcinoma No 22 21 12.07
Esophageal carcinoma No 28 20 13.70
Stomach adenocarcinoma No 25 15 9.32
Breast carcinoma No 13 13 1.13
Glioblastoma multiforme No 15 13 3.43
Uterine corpus endometrioid carcinoma No 10 10 4.35
Small cell lung carcinoma No 8 8 11.59
Bladder carcinoma No 7 6 6.12
Serous ovarian adenocarcinoma No 7 5 1.58
Colorectal adenocarcinoma No 9 5 2.18
Renal clear cell carcinoma No 5 4 0.96
Chronic lymphocytic leukemia No 9 3 1.03
Medulloblastoma No 3 2 0.95
Pancreas adenocarcinoma No 2 2 0.93
Thyroid carcinoma No 2 2 0.62
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 4 1 1.11
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
Non small cell lung carcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence