PTPN11 is detected as a mutational cancer driver in Glioblastoma Multiforme
PTPN11 reports in Glioblastoma Multiforme (GBM)
Cancer type details
| Glioblastoma Multiforme |
|---|
|
Cohorts
5
Samples 673 Mutations 3,702,787 Driver genes 52 |
Gene details
| PTPN11 |
|---|
|
Ensembl ID
ENSG00000179295
Transcript ID ENST00000635625 Protein ID ENSP00000489597 |
|
Cohorts where is driver
2
Mutated samples 14 Mutated samples (%) 2.08 Mutations 18 |
| Mode of action Activating |
| Known driver True |
Method signals per Cohort
| Cohort | Methods | Samples | Samples (%) |
|---|
ClustL
HotMAPS
smRegions
Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed
mutations along the protein sequence.
| Mutation (GRCh38) | Protein Position | Samples | Samples (%) | Consequence |
|---|