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PTPN11 is detected as a mutational cancer driver in 3 cancer types: Acute myeloid leukemia, Neuroblastoma, Glioblastoma multiforme and in the PAN-cancer analysis

PTPN11
Ensembl id ENSG00000179295
Mutated samples
Coding Sequence 83 (1.2%)
Protein Affecting 68 (1.0%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
AML FR
NB F
GBM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PTPN11 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Yes 10 9 2.30
Acute myeloid leukemia Yes 9 9 4.59
Neuroblastoma Yes 7 7 3.33
Glioblastoma multiforme Yes 5 5 1.32
Stomach adenocarcinoma Yes 4 4 2.48
Lung squamous cell carcinoma Yes 4 3 1.72
Lower grade glioma Yes 3 3 1.78
Uterine corpus endometrioid carcinoma Yes 4 2 0.87
Pylocytic astrocytoma Yes 2 2 1.98
Colorectal adenocarcinoma Yes 2 2 0.87
Cutaneous melanoma No 12 9 2.44
Acute lymphocytic leukemia No 3 3 2.46
Breast carcinoma No 2 2 0.17
Chronic lymphocytic leukemia No 4 2 0.69
Renal clear cell carcinoma No 3 1 0.24
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 3 1 1.45
Head and neck squamous cell carcinoma No 1 1 0.27
Diffuse B cell lymphoma No 1 1 4.35
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence