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PPP2CA has not been detected as a mutational cancer driver

PPP2CA
Ensembl id ENSG00000113575
Mutated samples
Coding Sequence 20 (0.3%)
Protein Affecting 11 (0.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PPP2CA gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 2 2 0.17
Serous ovarian adenocarcinoma No 2 2 0.63
Lung adenocarcinoma No 2 1 0.26
Bladder carcinoma No 2 1 1.02
Renal clear cell carcinoma No 1 1 0.24
Cutaneous melanoma No 3 1 0.27
Uterine corpus endometrioid carcinoma No 1 1 0.43
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Lung squamous cell carcinoma No 1 0 0.00
Stomach adenocarcinoma No 1 0 0.00
Head and neck squamous cell carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence