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PPHLN1 has not been detected as a mutational cancer driver

PPHLN1
Ensembl id ENSG00000134283
Mutated samples
Coding Sequence 88 (1.3%)
Protein Affecting 18 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PPHLN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 10 6 0.52
Head and neck squamous cell carcinoma No 7 3 0.80
Lung squamous cell carcinoma No 6 2 1.15
Cutaneous melanoma No 21 2 0.54
Lung adenocarcinoma No 3 1 0.26
Renal clear cell carcinoma No 3 1 0.24
Uterine corpus endometrioid carcinoma No 3 1 0.43
Serous ovarian adenocarcinoma No 4 1 0.32
Stomach adenocarcinoma No 6 1 0.62
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 6 0 0.00
Bladder carcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Multiple myeloma No 1 0 0.00
Lower grade glioma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Esophageal carcinoma No 4 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence