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PKD1L1 has not been detected as a mutational cancer driver

PKD1L1
Ensembl id ENSG00000158683
Mutated samples
Coding Sequence 215 (3.2%)
Protein Affecting 158 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PKD1L1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 71 51 13.82
Lung adenocarcinoma No 31 22 5.63
Breast carcinoma No 15 13 1.13
Uterine corpus endometrioid carcinoma No 14 11 4.78
Head and neck squamous cell carcinoma No 13 10 2.67
Serous ovarian adenocarcinoma No 10 8 2.53
Lung squamous cell carcinoma No 9 6 3.45
Bladder carcinoma No 8 5 5.10
Renal clear cell carcinoma No 4 4 0.96
Lower grade glioma No 5 4 2.37
Stomach adenocarcinoma No 7 4 2.48
Small cell lung carcinoma No 5 4 5.80
Glioblastoma multiforme No 5 4 1.06
Non small cell lung carcinoma No 3 3 9.68
Colorectal adenocarcinoma No 6 3 1.31
Chronic lymphocytic leukemia No 2 2 0.69
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Esophageal carcinoma No 2 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Medulloblastoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence