PITX2 has not been detected as a mutational cancer driver
| PITX2 |
|---|
| Ensembl id ENSG00000164093 |
| Mutated samples
Coding Sequence 43 (0.6%) Protein Affecting 34 (0.5%) |
| Mode of action Unclassified |
| Known driver No |
| Cancer type | Signals (Biases) |
|---|
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PITX2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.
| Cancer type | Driver | Mutated samples (CS) | Mutated samples (PAM) | % Mutated samples (PAM) |
|---|---|---|---|---|
| Cutaneous melanoma | No | 8 | 5 | 1.36 |
| Uterine corpus endometrioid carcinoma | No | 7 | 5 | 2.17 |
| Lung adenocarcinoma | No | 3 | 3 | 0.77 |
| Breast carcinoma | No | 3 | 3 | 0.26 |
| Lung squamous cell carcinoma | No | 3 | 3 | 1.72 |
| Glioblastoma multiforme | No | 3 | 3 | 0.79 |
| Stomach adenocarcinoma | No | 4 | 2 | 1.24 |
| Prostate adenocarcinoma | No | 1 | 1 | 0.41 |
| Bladder carcinoma | No | 1 | 1 | 1.02 |
| Renal clear cell carcinoma | No | 1 | 1 | 0.24 |
| Thyroid carcinoma | No | 1 | 1 | 0.31 |
| Neuroblastoma | No | 1 | 1 | 0.48 |
| Non small cell lung carcinoma | No | 2 | 1 | 3.23 |
| Lower grade glioma | No | 1 | 1 | 0.59 |
| Small cell lung carcinoma | No | 1 | 1 | 1.45 |
| Colorectal adenocarcinoma | No | 1 | 1 | 0.44 |
| Head and neck squamous cell carcinoma | No | 1 | 1 | 0.27 |
| Esophageal carcinoma | No | 1 | 0 | 0.00 |
Choose a transcript:
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.
| Variant Locus | Samples | AA pos | AA change | Consequence |
|---|