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PGR is detected as a mutational cancer driver in 1 cancer type: Uterine corpus endometrioid carcinoma

PGR
Ensembl id ENSG00000082175
Mutated samples
Coding Sequence 83 (1.2%)
Protein Affecting 56 (0.8%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
UCEC F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PGR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 8 6 2.61
Cutaneous melanoma No 18 12 3.25
Stomach adenocarcinoma No 10 7 4.35
Breast carcinoma No 6 6 0.52
Glioblastoma multiforme No 5 5 1.32
Lung adenocarcinoma No 4 4 1.02
Esophageal carcinoma No 5 4 2.74
Head and neck squamous cell carcinoma No 4 3 0.80
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Lung squamous cell carcinoma No 4 1 0.57
Pancreas adenocarcinoma No 2 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 4 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence