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PCDHGA8 has not been detected as a mutational cancer driver

PCDHGA8
Ensembl id ENSG00000253767
Mutated samples
Coding Sequence 611 (9.0%)
Protein Affecting 69 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PCDHGA8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 60 18 4.60
Cutaneous melanoma No 125 16 4.34
Lung squamous cell carcinoma No 43 6 3.45
Uterine corpus endometrioid carcinoma No 43 6 2.61
Bladder carcinoma No 26 5 5.10
Stomach adenocarcinoma No 37 5 3.11
Glioblastoma multiforme No 23 4 1.06
Renal clear cell carcinoma No 16 3 0.72
Head and neck squamous cell carcinoma No 62 3 0.80
Chronic lymphocytic leukemia No 6 1 0.34
Multiple myeloma No 3 1 1.45
Serous ovarian adenocarcinoma No 21 1 0.32
Prostate adenocarcinoma No 12 0 0.00
Hepatocarcinoma No 3 0 0.00
Acute myeloid leukemia No 3 0 0.00
Breast carcinoma No 49 0 0.00
Medulloblastoma No 3 0 0.00
Pancreas adenocarcinoma No 4 0 0.00
Thyroid carcinoma No 5 0 0.00
Lower grade glioma No 8 0 0.00
Small cell lung carcinoma No 2 0 0.00
Colorectal adenocarcinoma No 24 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Esophageal carcinoma No 30 0 0.00
Acute lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence