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PCDHGA6 has not been detected as a mutational cancer driver

PCDHGA6
Ensembl id ENSG00000253731
Mutated samples
Coding Sequence 778 (11.5%)
Protein Affecting 76 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PCDHGA6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 160 27 7.32
Lung adenocarcinoma No 80 13 3.32
Stomach adenocarcinoma No 54 9 5.59
Uterine corpus endometrioid carcinoma No 56 4 1.74
Colorectal adenocarcinoma No 31 4 1.75
Lung squamous cell carcinoma No 50 3 1.72
Head and neck squamous cell carcinoma No 78 3 0.80
Bladder carcinoma No 32 2 2.04
Breast carcinoma No 61 2 0.17
Chronic lymphocytic leukemia No 9 2 0.69
Glioblastoma multiforme No 32 2 0.53
Prostate adenocarcinoma No 15 1 0.41
Hepatocarcinoma No 4 1 1.11
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 22 1 0.32
Esophageal carcinoma No 35 1 0.68
Acute myeloid leukemia No 3 0 0.00
Medulloblastoma No 4 0 0.00
Pancreas adenocarcinoma No 4 0 0.00
Renal clear cell carcinoma No 22 0 0.00
Thyroid carcinoma No 6 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Multiple myeloma No 3 0 0.00
Lower grade glioma No 10 0 0.00
Small cell lung carcinoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Acute lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence