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PCDHGA5 has not been detected as a mutational cancer driver

PCDHGA5
Ensembl id ENSG00000253485
Mutated samples
Coding Sequence 885 (13.0%)
Protein Affecting 76 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PCDHGA5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 183 17 4.61
Lung adenocarcinoma No 92 13 3.32
Head and neck squamous cell carcinoma No 90 9 2.40
Lung squamous cell carcinoma No 58 5 2.87
Uterine corpus endometrioid carcinoma No 59 5 2.17
Stomach adenocarcinoma No 58 5 3.11
Breast carcinoma No 71 4 0.35
Serous ovarian adenocarcinoma No 26 4 1.27
Colorectal adenocarcinoma No 37 3 1.31
Esophageal carcinoma No 43 3 2.05
Bladder carcinoma No 35 2 2.04
Acute myeloid leukemia No 4 1 0.51
Renal clear cell carcinoma No 25 1 0.24
Thyroid carcinoma No 7 1 0.31
Chronic lymphocytic leukemia No 10 1 0.34
Lower grade glioma No 12 1 0.59
Glioblastoma multiforme No 36 1 0.26
Prostate adenocarcinoma No 15 0 0.00
Hepatocarcinoma No 4 0 0.00
Medulloblastoma No 5 0 0.00
Pancreas adenocarcinoma No 4 0 0.00
Neuroblastoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Multiple myeloma No 3 0 0.00
Small cell lung carcinoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Acute lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence