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PAX5 is detected as a mutational cancer driver in 1 cancer type: Head and neck squamous cell carcinoma and in the PAN-cancer analysis

PAX5
Ensembl id ENSG00000196092
Mutated samples
Coding Sequence 45 (0.7%)
Protein Affecting 30 (0.4%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
HNSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PAX5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 11 6 1.63
Lung adenocarcinoma Yes 6 5 1.28
Head and neck squamous cell carcinoma Yes 5 5 1.33
Lung squamous cell carcinoma Yes 3 3 1.72
Glioblastoma multiforme Yes 3 3 0.79
Breast carcinoma Yes 3 2 0.17
Esophageal carcinoma Yes 2 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Uterine corpus endometrioid carcinoma No 1 1 0.43
Diffuse B cell lymphoma No 3 1 4.35
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence