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NKX2-1 × Esophageal Adenocarcinoma ×

NKX2-1 is detected as a mutational cancer driver in Esophageal Adenocarcinoma

NKX2-1 reports in Esophageal Adenocarcinoma (ESCA)

Cancer type details
Esophageal Adenocarcinoma
Cohorts 8
Samples 1,139
Mutations 17,905,104
Driver genes 90
Gene details
NKX2-1
Ensembl ID ENSG00000136352
Transcript ID ENST00000354822
Protein ID ENSP00000346879
Cohorts where is driver 1
Mutated samples 4
Mutated samples (%) 0.35
Mutations 13
Mode of action Activating
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence