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NF2 mutations in 5 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Breast carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Lower grade glioma

NF2
Ensembl id ENSG00000186575
Mutated samples
Coding Sequence 41 (0.6%)
Protein Affecting 33 (0.5%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NF2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 11 8 2.17
Lung adenocarcinoma Yes 3 3 0.77
Breast carcinoma Yes 4 3 0.26
Uterine corpus endometrioid carcinoma Yes 2 2 0.87
Lower grade glioma Yes 2 2 1.18
Renal clear cell carcinoma No 4 4 0.96
Head and neck squamous cell carcinoma No 4 4 1.07
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 1 1 1.02
Lung squamous cell carcinoma No 2 1 0.57
Thyroid carcinoma No 1 1 0.31
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence