NF1 mutations in 1 Small cell lung carcinoma project possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Small cell lung carcinoma
Projects 2
69 Samples
Coding sequence mutations (CSMs)
in driver genes 299
in all genes 22075
Protein affecting mutations (PAMs)
in driver genes 281
in all genes 14252
Ensembl id ENSG00000196712
Mutated samples
Coding Sequence 3 (4.3%)
Protein Affecting 3 (4.3%)
Mode of action Loss of function
Known driver Yes
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Small cell lung carcinoma projects in all NF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Small cell lung cancer University of Cologne Yes 2 2 2.90
Small cell lung cancer Johns Hopkins University No 1 1 1.45
The mutations needle plot shows the distribution of the observed NF1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification