NCK1 mutations in 4 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Lung squamous cell carcinoma, Thyroid carcinoma, Stomach adenocarcinoma

Ensembl id ENSG00000158092
Mutated samples
Coding Sequence 29 (0.4%)
Protein Affecting 22 (0.3%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NCK1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma Yes 4 4 2.48
Lung adenocarcinoma Yes 2 2 0.51
Lung squamous cell carcinoma Yes 3 2 1.15
Thyroid carcinoma Yes 2 2 0.62
Head and neck squamous cell carcinoma No 5 5 1.33
Uterine corpus endometrioid carcinoma No 2 2 0.87
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 1 1 0.09
Pancreas adenocarcinoma No 1 1 0.47
Cutaneous melanoma No 2 1 0.27
Small cell lung carcinoma No 1 1 1.45
Hepatocarcinoma No 2 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence