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MYO9A has not been detected as a mutational cancer driver

MYO9A
Ensembl id ENSG00000066933
Mutated samples
Coding Sequence 144 (2.1%)
Protein Affecting 100 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MYO9A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 46 30 8.13
Breast carcinoma No 16 13 1.13
Lung adenocarcinoma No 9 8 2.05
Uterine corpus endometrioid carcinoma No 7 7 3.04
Stomach adenocarcinoma No 8 7 4.35
Head and neck squamous cell carcinoma No 10 6 1.60
Lung squamous cell carcinoma No 5 5 2.87
Small cell lung carcinoma No 3 3 4.35
Colorectal adenocarcinoma No 7 3 1.31
Prostate adenocarcinoma No 2 2 0.82
Renal clear cell carcinoma No 2 2 0.48
Chronic lymphocytic leukemia No 7 2 0.69
Multiple myeloma No 2 2 2.90
Hepatocarcinoma No 3 1 1.11
Bladder carcinoma No 2 1 1.02
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 4 1 0.47
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence